BioMedSyn

FACTOR XIIIFACTOR XIII CONCENTRATE (HUMAN)FIBROGAMMIN P

US: Corifact

Approved 2011. Label updated: 20200818

A concentrate of coagulation factor XIII (FXIII), a heterotetramer that contains two enzymatic A-subunits and two non-enzymatic B-subunits, derived from pooled human plasma from donors, that can be used for prophylactic treatment to prevent bleeding episodes and to avoid surgical bleeds in patients with congenital FXIII deficiency. Upon intravenous administration of human FXIII concentrate, FXIII replaces missing endogenous FXIII. FXIII is activated by thrombin to its activated form FXIIIa, a transglutaminase enzyme that consists of a dimer of two active A units. FXIIIa promotes crosslinking of fibrin during coagulation, thereby stabilizing fibrin clots and protecting the fibrin clots against fibrinolysis, and preventing bleeding. FXIII, also called fibrin stabilizing factor, is an endogenous plasma glycoprotein.